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GSK2850163

CAT: 0804-HY-U00459-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00459-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.
CAS Number
2121989-91-9
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2850163.html
Purity
98.25
Solubility
DMSO : 67.5 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1)C[C@]21CCN(CC3=CC=C(Cl)C(Cl)=C3)C2)NCC4=CC=C(C)C=C4
Molecular Formula
C24H29Cl2N3O
Molecular Weight
446.41
References & Citations
[1]Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3614880-01GSK2850163
T63198-01GSK2850163 hydrochloride
MBS5825401GSK2850163 (S enantiomer)
T11489-01GSK2850163 S enantiomer
T11488L-01GSK2850163 hydrochloride (2121989-91-9 free base)

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