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SE-7552

CAT: 0804-HY-161305-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-161305-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SE-7552, a 2- (difluoromethyl) -1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. SE-7552 is greater than 850-fold selectivity versus all other known HDAC isozymes. SE-7552 is capable of blocking multiple myeloma growth in vivo. SE-7552 acts as an anti-obesity agent in diet-induced obese mice[1][2].
CAS Number
[2243575-79-1]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/se-7552.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)C(O1)=NN=C1C(C=N2)=CN=C2NC(C)C3=CC=C(F)C=C3
Molecular Formula
C15H12F3N5O
Molecular Weight
335.28
References & Citations
[1]Jason A Holt, et al. SE-7552, a Highly Selective, Non-Hydroxamate Inhibitor of Histone Deacetylase-6 Blocks Multiple Myeloma Growth In Vivo. Blood (2018) 132 (Supplement 1) : 3215.|[2]Beate König, et al. 2- (Difluoromethyl) -1,3,4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation? ACS Pharmacol. Transl. Sci. 2024, February 20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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