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TRPV1 antibody

CAT: 0710-FNab10732Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10732Size:100 µg
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Background
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
Synonyms
Transient receptor potential cation channel subfamily V member 1 (TrpV1) |Capsaicin receptor|Osm-9-like TRP channel 1 (OTRPC1) |Vanilloid receptor 1|TRPV1|VR1
UniProt
Q8NER1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Centromere protein H
Target
TRPV1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
688-839aa

UniProtKB · Q8NER1

Transient receptor potential cation channel subfamily V member 1

TRPV1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NER1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TRPV1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TrpV1
EC number
—
Processing
—
Secondary accessions
A2RUA9, Q3LU47, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeatTransmembraneTransmembrane helix

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingSodium

Molecular function

Calcium channelCalmodulin-bindingIon channel

Biological process

Calcium transportIon transportTransport

Cellular component

Cell membraneCell projectionMembranePostsynaptic cell membraneSynapse

PTM

GlycoproteinPhosphoprotein

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