TRPV6 antibody

• Background:

  Calcium selective cation channel that mediates Ca (2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980) . Important for normal Ca (2+) ion homeostasis in the body, including bone and skin (By similarity) . The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369) . Inactivation includes both a rapid Ca (2+) -dependent and a slower Ca (2+) -calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg (2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

• Synonyms:

  Transient receptor potential cation channel subfamily V member 6 (TrpV6) |CaT-like (CaT-L) |Calcium transport protein 1 (CaT1) |Epithelial calcium channel 2 (ECaC2) |TRPV6|ECAC2

• Gene ID:

  55503

• UniProt:

  Q9H1D0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Transient receptor potential cation channel, subfamily V, member 6

• Target:

  TRPV6

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IF, WB, IP

• Field of Research:

  Cancer

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  82 kDa, 70 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IF, WB, IP