CAPS1 rabbit pAb

CAT: 0855-ES17862-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES17862-01Size:50 µL
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Background
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) . Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Description
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate (PtdIns (4, 5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008],
UniProt
Q9ULU8
Swiss Prot
Q9ULU8
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human CAPS1 AA range: 1275-1325
Target
CAPS1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell junction, synapse . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane ; Peripheral membrane protein . Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns (4,5) P2 over PtdIns (3,4,5) P3. Probably localizes to different vesicles compared to CADPS2. .
Gene ID (Human)
8618

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