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RTC-5

CAT: 0804-HY-123952-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123952-04Size:25 mg
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Description
RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1].
CAS Number
1423077-49-9
Product Name Alternative
TRC-382
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rtc-5.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 15 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(OC(F)(F)F)C=C1)(NCCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)=O
Molecular Formula
C24H22ClF3N2O3S
Molecular Weight
510.96
References & Citations
[1]Kastrinsky DB, et al. Reengineered tricyclic anti-cancer agents. Bioorg Med Chem. 2015 Oct 1;23 (19) :6528-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-4-(trifluoromethoxy)benzenesulfonamide
CAS Number1423077-49-9
PubChem CID71263344
IUPAC NameN-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-(trifluoromethoxy)benzenesulfonamide
Molecular FormulaC24H22ClF3N2O3S
Molecular Weight511.0
XLogP7
Topological Polar Surface Area67
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity756
SMILES
C1CC2=CC=CC=C2N(C3=C1C=CC(=C3)Cl)CCCNS(=O)(=O)C4=CC=C(C=C4)OC(F)(F)F
InChI
InChI=1S/C24H22ClF3N2O3S/c25-19-9-8-18-7-6-17-4-1-2-5-22(17)30(23(18)16-19)15-3-14-29-34(31,32)21-12-10-20(11-13-21)33-24(26,27)28/h1-2,4-5,8-13,16,29H,3,6-7,14-15H2
InChIKey
QYOJMNDDVVEPFN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-4-(trifluoromethoxy)benzenesulfonamide
CAS: 1423077-49-9
CID: 71263344
Formula: C24H22ClF3N2O3S
MW: 511.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight511.0
XLogP37
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass510.0991759
Monoisotopic Mass510.0991759
Topological Polar Surface Area67 Ų
Heavy Atom Count34
Formal Charge0
Complexity756
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BUP10966-01RTC-5
A19067-25RTC-5 25mg
A19067-5RTC-5 5mg
A19067-500RTC-5 500mg
A19067-50RTC-5 50mg
A19067-100RTC-5 100mg
A19067-10RTC-5 10mg
A19067-10mM-DRTC-5 10mM * 1mL in DMSO
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A18865-1RTC-30 1mg

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