FGFR1 inhibitor-11

FGFR1 inhibitor-11

• CAS Number: 2157482-40-9
• UNSPSC Description: FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity[1].
• Target Antigen: FGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/fgfr1-inhibitor-11.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C(C=C1)C2=C(C(C3=CC=CC=C3O2)=O)CC4=C(C=CC=C4)O
• Molecular Weight: 358.39
• References & Citations: [1]Zhihao Chen, et al. Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1. Eur J Med Chem. 2024 Mar 27:270:116335.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported