FGFR1 inhibitor-10

FGFR1 inhibitor-10

• CAS Number: 2426769-76-6
• UNSPSC Description: FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC50: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect[1].
• Target Antigen: FGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fgfr1-inhibitor-10.html
• Solubility: DMSO : 14.29 mg/mL (ultrasonic;adjust pH to 2 with 1 M HCL)
• Smiles: O=C(C1=C(NC2=NC(NC3=CC=C(N4CCC(N5CCOCC5)CC4)C=C3)=NC=C2C(F)(F)F)SC=C1)NC
• Molecular Weight: 561.62
• References & Citations: [1]Li YL, et al. Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme. Eur J Med Chem. 2023 Nov 15;260:115764.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported