FGFR1 inhibitor 7

FGFR1 inhibitor 7

• UNSPSC Description: FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC50 value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC50 of 2.1 μM[1].
• Target Antigen: FGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/fgfr1-inhibitor-7.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(Cl)=C(NC2=CC=CC(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)C(C4=C1C=CC=C4)=O
• Molecular Weight: 429.85
• References & Citations: [1]Leechaisit R, et al. Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling[J]. ACS Omega, 2023. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported