UCB-6876
CAT:
804-HY-156454-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
UCB-6876
- CAS Number: 637324-45-9
- UNSPSC Description: UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD=22 μM)[1][2].
- Target Antigen: TNF Receptor
- Type: Reference compound
- Related Pathways: Apoptosis
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/ucb-6876.html
- Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
- Smiles: OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2
- Molecular Weight: 266.34
- References & Citations: [1]Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90.|[2]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported