KB02-SLF
CAT:
804-HY-129610-02
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KB02-SLF
- CAS Number: 2384184-40-9
- UNSPSC Description: KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF[1].
- Target Antigen: FKBP; PROTACs
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kb02-slf.html
- Purity: 99.25
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5
- Molecular Weight: 949.52
- References & Citations: [1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported