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ONCOII

CAT: 0804-HY-164516Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164516Size:1 Each
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Description
ONCOII is an Mps1 inhibitor with an IC50 of 10.8 nM. The inhibitory activity of ONCOII against Mps1 is affected by naturally occurring mutations in the Mps1 gene, and cells with Mps1 mutations exhibit increased resistance to ONCOII. ONCOII can be used in cancer research[1].
CAS Number
1263564-94-8
UNSPSC
12352005
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oncoii.html
Smiles
N#CC1=CC=C(NC2=CC(OCC#N)=C(C3=CN(C)N=C3)C=C2)N=C1NC4CCCCC4
Molecular Formula
C24H25N7O
Molecular Weight
427.50
References & Citations
[1]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75 (16) :3340-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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