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Oncocin

CAT: 0804-HY-P11080Size: 1 EachDry Ice: NoHazardous: No
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Description
Oncocin is an antibacterial peptide. It belongs to proline-rich antimicrobial peptides (PrAMPs) . Oncocin works against Gram-negative bacteria. It has MIC values of 0.125-8 μg/mL for 34 strains and clinical isolates of Enterobacteriaceae and nonfermenters. Oncocin binds to the substrate-binding domain of the chaperone DnaK. The binding has dissociation constants in the micromolar range. This binding causes protein misfolding and aggregation and the bacteria death[1][2].
CAS Number
1235497-90-1
UNSPSC
12352209
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Molecular Formula
C109H177N37O24
Molecular Weight
2389.81
References & Citations
[1]Roy RN, et al. The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Nat Struct Mol Biol. 2015 Jun;22 (6) :466-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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