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Maresin 1-d5

CAT: 0804-HY-116429S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116429S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maresin 1-d5 is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].
Product Name Alternative
CC 122, CC 122 (hydrochloride)
UNSPSC
12352211
Target
Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O[C@H](/C=C\C=C\C=C\[C@@H](C/C=C\CCC(O)=O)O)C/C=C\C/C=C\C([2H])(C([2H])([2H])[2H])[2H]
Molecular Formula
C22H27D5O4
Molecular Weight
365.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8.|[3]Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain|[4]Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191 (8) :4288-98.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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