Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

• UNSPSC Description:

  Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/propargyl-peg5-1-o-b-cyanoethyl-n-n-diisopropyl-phosphoramidite.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C#CCOCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N

• Molecular Weight:

  432.49

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1682657-14-2