Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

• CAS Number: 1682657-14-2
• UNSPSC Description: Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/propargyl-peg5-1-o-b-cyanoethyl-n-n-diisopropyl-phosphoramidite.html
• Solubility: 10 mM in DMSO
• Smiles: C#CCOCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N
• Molecular Weight: 432.49
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported