CSD-CH2(1,8)-NH2

CSD-CH2(1,8)-NH2

• CAS Number: 3032600-19-1
• UNSPSC Description: CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (Ki: 6.8 nM). CSD-CH2(1,8)-NH2 inhibits calcium mobilization in DRG neurons. CH2(1,8)-NH2 antagonizes the antinociceptive effect of U50,488. CSD-CH2(1,8)-NH2 can be used for research of neuropsychiatric disorders[1].
• Target Antigen: Opioid Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/csd-ch2-1-8-nh2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@H](C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@H]2CCCNC(N)=N)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)CCSCSC[C@@H](C(N[C@H](C(N4CCC[C@H]4C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCCN)=O)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)NC([C@@H](NC2=O)CCCNC(N)=N)=O
• Molecular Weight: 1693.09
• References & Citations: [1]Muratspahić E, et al. Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. J Med Chem. 2023 Sep 14;66(17):11843-11854.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported