THIP-d4

CAT: 0804-HY-10232SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-10232SSize:1 Each
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Description
THIP-d4 (Gaboxadol-d4) is the deuterium labeled THIP (HY-10232) . THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders[1][2][3].
CAS Number
[2748778-97-2]
Product Name Alternative
Gaboxadol-d4
UNSPSC
12352005
Target
GABA Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C1C2=C(ON1)CNC([2H])([2H])C2([2H])[2H]
Molecular Formula
C6H4D4N2O2
Molecular Weight
144.16
References & Citations
[1]Drasbek KR, et al. THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex. Cereb Cortex. 2006 Aug;16 (8) :1134-41. |[2]Larsen M, et al. 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. Eur J Pharm Sci. 2010 Jan 31;39 (1-3) :68-75. |[3]Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34 (49) :16256-72.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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