Glucosylceramide synthase-IN-2
CAT:
804-HY-144267-03
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Glucosylceramide synthase-IN-2
- CAS Number: 2597958-02-4
- UNSPSC Description: Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].
- Target Antigen: Glucosylceramide Synthase (GCS)
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/glucosylceramide-synthase-in-2.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(C1=CC=NN(C1=O)C2=C(OCC(F)(F)F)C=CC=C2)NC3=CC=C(C(C)(O)C)C=C3
- Molecular Weight: 447.41
- References & Citations: [1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported