Glucosylceramide synthase-IN-3

Glucosylceramide synthase-IN-3

• CAS Number: 3029827-91-3
• UNSPSC Description: Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research[1][2].
• Target Antigen: Glucosylceramide Synthase (GCS)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/glucosylceramide-synthase-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O[C@H]1CN2CCC1CC2)NC3=CC=CC4=C3N=C(O4)C5=CC=C(C=C5)F
• Molecular Weight: 381.40
• References & Citations: [1]Mali Cosden, et al. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiol Dis. 2021 Nov;159:105507.|[2]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported