Glucosylceramide synthase-IN-4

CAT:

804-HY-163131

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CAS Number: 2776965-41-2
UNSPSC Description: Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
Target Antigen: Glucosylceramide Synthase (GCS)
Type: Reference compound
Related Pathways: Neuronal Signaling
Applications: Neuroscience-Neuromodulation
Field of Research: Neurological Disease
Assay Protocol: https://www.medchemexpress.com/glucosylceramide-synthase-in-4.html
Solubility: 10 mM in DMSO
Smiles: CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
Molecular Weight: 467.39
References & Citations: [1]H. Marie Loughran, et al. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med. Chem. Lett. 2024, 15, 1, 123-131.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-163131	Glucosylceramide synthase-IN-4
HY-144267-05	Glucosylceramide synthase-IN-2
HY-144267-04	Glucosylceramide synthase-IN-2
HY-144267-02	Glucosylceramide synthase-IN-2
HY-144267-01	Glucosylceramide synthase-IN-2
HY-144270	Glucosylceramide synthase-IN-3
HY-144267-06	Glucosylceramide synthase-IN-2
HY-144267-03	Glucosylceramide synthase-IN-2
HY-W717504	Glucosylceramide, plant
HY-165035-02	Glucosylceramide (gaucher's spleen)

Cat	Name
T61632-1mg	Glucosylceramide synthase-IN-3
T62664-1mg	Glucosylceramide synthase-IN-2
T61632-5mg	Glucosylceramide synthase-IN-3
T61632-1g	Glucosylceramide synthase-IN-3
T62664-5mg	Glucosylceramide synthase-IN-2
T62898-5mg	Glucosylceramide synthase-IN-1
T61632-10mg	Glucosylceramide synthase-IN-3
T61632-50mg	Glucosylceramide synthase-IN-3
T62664-1g	Glucosylceramide synthase-IN-2
T62664-50mg	Glucosylceramide synthase-IN-2