N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine

• CAS Number: 440327-50-4
• UNSPSC Description: N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/n2-iso-butyryl-2-o-2-methoxyethyl-guanosine.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@@H]1[C@@H](O)[C@@H](OCCOC)[C@H](N2C=NC3=C2N=C(NC3=O)NC(C(C)C)=O)O1
• Molecular Weight: 411.41
• References & Citations: [1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported