3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine

3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine

• UNSPSC Description: 3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/3-o-dmt-n2-isobutyryl-2-o-2-methoxyethyl-guanosine.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(N([C@@H]([C@@H]3OCCOC)O[C@@H]([C@H]3OC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)CO)C=N2)N=C(NC(C(C)C)=O)N1
• Molecular Weight: 713.78
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported