3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine

• UNSPSC Description:

  3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-o-dmt-n2-isobutyryl-2-o-2-methoxyethyl-guanosine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N([C@@H]([C@@H]3OCCOC)O[C@@H]([C@H]3OC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)CO)C=N2)N=C(NC(C(C)C)=O)N1

• Molecular Weight:

  713.78

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported