2′-O-(2-Methoxyethyl)guanosine

2′-O-(2-Methoxyethyl)guanosine

• CAS Number: 473278-54-5
• UNSPSC Description: 2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Biochemical Assay Reagents
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-o-2-methoxyethyl-guanosine.html
• Purity: 99.81
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O[C@H]1[C@@H](OCCOC)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1CO
• Molecular Weight: 341.324
• References & Citations: [1]McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.|[2]Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported