(R,R)-CXCR2-IN-2

(R,R)-CXCR2-IN-2

• CAS Number: 1838123-22-0
• UNSPSC Description: (R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].
• Target Antigen: CXCR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/r-r-cxcr2-in-2.html
• Purity: 99.37
• Solubility: DMSO : 220 mg/mL (ultrasonic)
• Smiles: O=S(C1=C(C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)O)([C@@]3(CCOC3)C)=O
• Molecular Weight: 414.90
• References & Citations: [1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported