Mca-PLAQAV-Dpa-RSSSR-NH2

• CAS Number:

  192723-42-5

• UNSPSC Description:

  Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis[1].

• Target Antigen:

  Fluorescent Dye; MMP

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/mca-endo-1a-dap-dnp-tnf-alpha-5-to-6-amide-human.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C(C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CNC2=C(N(=O)=O)C=C(N(=O)=O)C=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CO)=O)CO)=O)CO)=O)CCCNC(=N)N)=O)=O)C(C)C)=O)C)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)CCC1)C=3C=4C(=CC(OC)=CC4)OC(=O)C3

• Molecular Weight:

  1638.70

• References & Citations:

  [1]Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017.|[2]Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5.|[3]Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6. |[4]Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported