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DPA-714

CAT: 0804-HY-122607-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122607-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].
CAS Number
958233-07-3
UNSPSC
12352005
Target
Mitochondrial Metabolism; TSPO
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dpa-714.html
Purity
99.86
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N(CC)CC)CC1=C2N=C(C)C=C(C)N2N=C1C3=CC=C(OCCF)C=C3
Molecular Formula
C22H27FN4O2
Molecular Weight
398.47
References & Citations
[1]James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49 (5) :814-22.|[2]Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8 (8) :e69529.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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Alternative Products

CatalogName
M25016-01DPA-714
A18585-50DPA-714 50mg
A18585-25DPA-714 25mg
A18585-5DPA-714 5mg
A18585-100DPA-714 100mg
A18585-10DPA-714 10mg
A18585-200DPA-714 200mg
A18585-1DPA-714 1mg
A18585-10mM-DDPA-714 10mM * 1mL in DMSO
#60037DPA

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