TPC2-A1-P

• UNSPSC Description:

  TPC2-A1-P is a powerful and membrane permeable agonist of?two pore?channel?2?(TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions?of?PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/tpc2-a1-p.html

• Purity:

  99.76

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  BrC1=CC(C2=CC(C(O)=O)=C(C)N2CC3CCCCC3)=C(OC(F)(F)F)C=C1

• Molecular Weight:

  460.28

• References & Citations:

  [1]Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.|[2]Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41(8):582-594.|[3]Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287(24):5284-5293.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2804595-86-4