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TPC2-A1-P

CAT: 0804-HY-131615-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131615-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI (3,5) P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N. TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3].
CAS Number
2804595-86-4
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tpc2-a1-p.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
BrC1=CC(C2=CC(C(O)=O)=C(C)N2CC3CCCCC3)=C(OC(F)(F)F)C=C1
Molecular Formula
C20H21BrF3NO3
Molecular Weight
460.28
References & Citations
[1]Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.|[2]Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41 (8) :582-594.|[3]Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287 (24) :5284-5293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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