CAP-53194

CAT: 0804-HY-123702Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123702Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing[1].
CAS Number
[660817-08-3]
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cap-53194.html
Smiles
O=C(NC1=CC=C(C=C1)[N+]([O-])=O)C2=C(N(N=N2)C3=CC=C(C=C3)[N+]([O-])=O)C4=CC=CC=C4
Molecular Formula
C21H14N6O5
Molecular Weight
430.37
References & Citations
[1]Identification of a high affinity selective inhibitor of Polo-like kinase 1 for cancer chemotherapy by computational approach
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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