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Cap-dependent endonuclease-IN-28

CAT: 0804-HY-163621Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163621Size:1 Each
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Description
Cap-dependent endonuclease-IN-28 (Compound 11) is a potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-28 inhibits CEN of TOSV, ANDV, and LACV viruses with IC50 values ​​of 2.4, 0.5, and 4 μM, respectively[1].
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cap-dependent-endonuclease-in-28.html
Smiles
O=C1N(CC2=CC=C(O)C(O)=C2)CC3=C1C(O)=C(O)C=C3
Molecular Formula
C15H13NO5
Molecular Weight
287.27
References & Citations
[1]Miglioli F, et al. Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features. Eur J Med Chem. 2024 Jun 5;272:116467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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