Products for Research Use Only
RegisterLogin

Adefovir-d4

CAT: 0804-HY-B1826S2Size: 2.5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1826S2Size:2.5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].
CAS Number
1190021-70-5
Product Name Alternative
GS-0393-d4; PMEA-d4
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
HBV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Purity
98.69
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)COC([2H])([2H])C([2H])([2H])N1C2=NC=NC(N)=C2N=C1
Molecular Formula
C8H8D4N5O4P
Molecular Weight
277.21
Precautions
H301, H312, H330, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.|[3]Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348 (9) :808-16.|[4]Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W739906-01Adefovir Diethyl Ester-d4
HY-B1826-01Adefovir
HY-168165Adefovir diphosphate
HY-B0255-01Adefovir dipivoxil
HY-B0255R-01Adefovir dipivoxil (Standard)
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)
HY-151910S(±) -Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy)

Alternative Products

CatalogName
TRC-A247502-2.5MGAdefovir-d4
TRC-A628917-2.5MGAdefovir-d4 Diethyl Ester
sc-217582Adefovir-d4, Diethyl Ester
sc-480730Adefovir-d4 Phosphate Triethylamine Salt
sc-480671Adefovir-d4 Diphosphate Triethylamine Salt
A0859Q-01Adefovir

Popular Products