Adefovir

CAT: 0804-HY-B1826-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1826-01Size:25 mg
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Description
Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].
CAS Number
[106941-25-7]
Product Name Alternative
GS-0393; PMEA
UNSPSC
12352005
Hazard Statement
H301
Target
HBV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/adefovir.html
Purity
99.74
Solubility
0.1 M NaOH : 10 mg/mL (ultrasonic; adjust pH to 10 with NaOH) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1
Molecular Formula
C8H12N5O4P
Molecular Weight
273.19
Precautions
H301
References & Citations
[1]X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.|[2]Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348 (9) :808-16.|[3]Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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