Adefovir

• UNSPSC Description:

  Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

• Target Antigen:

  HBV; Reverse Transcriptase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/adefovir.html

• Purity:

  99.74

• Solubility:

  0.1 M NaOH : 10 mg/mL (ultrasonic;adjust pH to 10 with NaOH)|DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1

• Molecular Weight:

  273.189

• References & Citations:

  [1]X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.|[2]Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16.|[3]Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  106941-25-7