Ethyl ferulate
CAT:
804-HY-N0061-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Ethyl ferulate
- CAS Number: 4046-02-0
- UNSPSC Description: Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].
- Target Antigen: Reactive Oxygen Species
- Type: Natural Products
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Ethyl_ferulate.html
- Purity: 99.89
- Solubility: DMSO : ≥ 100 mg/mL
- Smiles: O=C(OCC)/C=C/C1=CC=C(O)C(OC)=C1
- Molecular Weight: 222.24
- References & Citations: [1]Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8.|[2]Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.|[3]Wang Y, et al. Ethyl ferulate contributes to the inhibition of the inflammatory responses in murine RAW 264.7 macrophage cells and acute lung injury in mice. PLoS One. 2021 May 26;16(5):e0251578. |[4]Wu YX, et al. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. Acta Pharmacol Sin. 2021 Dec;42(12):2069-2081. |[5]Xue R, et al. Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model. Phytomedicine. 2023 Dec;121:155097.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, stored under nitrogen)
- Clinical Information: No Development Reported