Ethyl ferulate

CAT: 0804-HY-N0061-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0061-01Size:500 mg
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Description
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42) -induced oxidative stress and neurotoxicity[2].
CAS Number
[4046-02-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ethyl_ferulate.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCC)/C=C/C1=CC=C(O)C(OC)=C1
Molecular Formula
C12H14O4
Molecular Weight
222.24
Precautions
H315, H319, H335
References & Citations
[1]Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6 (5) :811-8.|[2]Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide (1-42) -induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92 (4) :749-58.|[3]Wang Y, et al. Ethyl ferulate contributes to the inhibition of the inflammatory responses in murine RAW 264.7 macrophage cells and acute lung injury in mice. PLoS One. 2021 May 26;16 (5) :e0251578. |[4]Wu YX, et al. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. Acta Pharmacol Sin. 2021 Dec;42 (12) :2069-2081. |[5]Xue R, et al. Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model. Phytomedicine. 2023 Dec;121:155097.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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