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RC-33 (hydrochloride)

CAT: 0804-HY-130179Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130179Size:1 Each
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Description
RC-33 hydrochloride is a selective and metabolically stable σ receptor agonist with activity in enhancing nerve growth factor (NGF) -induced neurite outgrowth. Both enantiomers of RC-33 hydrochloride bind to the σ receptor with similar affinity and show almost equal effectiveness as σ receptor agonists. The R-configured enantiomer of RC-33 hydrochloride shows higher liver metabolic stability in the presence of NADPH. RC-33 hydrochloride was selected as the best candidate for further in vivo studies in animal models of amyotrophic lateral sclerosis[1].
CAS Number
1346016-43-0
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rc-33-hydrochloride.html
Smiles
CC(C1=CC=C(C2=CC=CC=C2)C=C1)CCN3CCCCC3.Cl
Molecular Formula
C21H28ClN
Molecular Weight
329.91
References & Citations
[1]Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ₁ receptor agonists
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

RC-33 Hydrochloride
CAS Number1346016-43-0
PubChem CID46893280
IUPAC Name1-[3-(4-phenylphenyl)butyl]piperidine;hydrochloride
Molecular FormulaC21H28ClN
Molecular Weight329.9
Topological Polar Surface Area3.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity293
SMILES
CC(CCN1CCCCC1)C2=CC=C(C=C2)C3=CC=CC=C3.Cl
InChI
InChI=1S/C21H27N.ClH/c1-18(14-17-22-15-6-3-7-16-22)19-10-12-21(13-11-19)20-8-4-2-5-9-20;/h2,4-5,8-13,18H,3,6-7,14-17H2,1H3;1H
InChIKey
IYZBMSKKZQBBKD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of RC-33 Hydrochloride
CAS: 1346016-43-0
CID: 46893280
Formula: C21H28ClN
MW: 329.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight329.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count5
Exact Mass329.1910276
Monoisotopic Mass329.1910276
Topological Polar Surface Area3.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity293
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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