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CHIKV-IN-2

CAT: 0804-HY-132174-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132174-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools[1].
CAS Number
2361289-44-1
UNSPSC
12352005
Target
CHIKV; Dengue Virus; Dihydroorotate Dehydrogenase; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/chikv-in-2.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(C)(C)C#N)C=C1)C2=CC3=C(CCCCC3)C=C2OC
Molecular Formula
C23H26N2O2
Molecular Weight
362.46
References & Citations
[1]Ahmed SK, et, al. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64 (8) :4762-4786.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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