CHIKV-IN-2

• Description :

  CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools[1].

• UNSPSC :

  12352005

• Target :

  CHIKV; Dengue Virus; Dihydroorotate Dehydrogenase; Flavivirus

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/chikv-in-2.html

• Purity :

  99.21

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=C(C(C)(C)C#N)C=C1)C2=CC3=C(CCCCC3)C=C2OC

• Molecular Formula :

  C23H26N2O2

• Molecular Weight :

  362.46

• References & Citations :

  [1]Ahmed SK, et, al. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64 (8) :4762-4786.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2361289-44-1]