Aldose reductase-IN-7

Aldose reductase-IN-7

• UNSPSC Description: Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity[1].
• Target Antigen: Aldose Reductase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/aldose-reductase-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OCC)CN(C1=CC=C([N+]([O-])=O)C=C1C23OC(CC4=CC=C(OC)C=C4)=NN3)C2=O
• Molecular Weight: 440.41
• References & Citations: [1]Güleç Ö,  et al. Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies. Bioorg Chem. 2024 Apr;145:107221.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported