Aldose reductase-IN-3

Aldose reductase-IN-3

• CAS Number: 1390616-76-8
• UNSPSC Description: Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis[1].
• Target Antigen: Aldose Reductase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/aldose-reductase-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N=C(NC2=NC3=CC=C(OC)C=C3S2)S/C1=C\C4=CC=C(Cl)C=C4
• Molecular Weight: 401.89
• References & Citations: [1]Kousaxidis A, et al. Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis [published online ahead of print, 2021 Aug 4]. Med Chem Res. 2021;1-12.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported