ANI-7

• Description :

  ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].

• Product Name Alternative :

  Prodigiosine (hydrochloride)

• UNSPSC :

  12352005

• Target :

  Aryl Hydrocarbon Receptor; Checkpoint Kinase (Chk)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ani-7.html

• Concentration :

  10mM

• Purity :

  99.01

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC(/C(C#N)=C/C2=CC=CN2)=CC=C1Cl

• Molecular Formula :

  C13H8Cl2N2

• Molecular Weight :

  263.12

• References & Citations :

  [1]ilbert J, et al. (Z) -2- (3,4-Dichlorophenyl) -3- (1H-Pyrrol-2-yl) Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018 Feb;93 (2) :168-177.|[2]Baker JR, et al. Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro. ChemMedChem. 2018 Jul 18;13 (14) :1447-1458.|[3]Mark Tarleton, et al. Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. Medicinal Chemistry Communication. January 20112. (1) :31-37.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Chk2

• CAS Number :

  [931417-26-4]