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ANI-7

CAT: 0804-HY-117102-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117102-01Size:5 mg
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Description
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].
CAS Number
931417-26-4
Product Name Alternative
Prodigiosine (hydrochloride)
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ani-7.html
Concentration
10mM
Purity
99.01
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
ClC1=CC(/C(C#N)=C/C2=CC=CN2)=CC=C1Cl
Molecular Formula
C13H8Cl2N2
Molecular Weight
263.12
References & Citations
[1]ilbert J, et al. (Z) -2- (3,4-Dichlorophenyl) -3- (1H-Pyrrol-2-yl) Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018 Feb;93 (2) :168-177.|[2]Baker JR, et al. Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro. ChemMedChem. 2018 Jul 18;13 (14) :1447-1458.|[3]Mark Tarleton, et al. Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. Medicinal Chemistry Communication. January 20112. (1) :31-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk2

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