GITR, Mouse (HEK293, His)

GITR, Mouse (HEK293, His)

• UNSPSC Description: GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes[1]. GITR Protein, Mouse (HEK293, His) is a recombinant protein with a C-terminal His label and is produced in HEK293 cells.
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/gitr-protein-mouse-hek293-his.html
• Purity: 96.00
• Smiles: SVVEEPGCGP GKVQNGSGNN TRCCSLYAPG KEDCPKERCI CVTPEYHCGD PQCKICKHYP CQPGQRVESQ GDIVFGFRCV ACAMGTFSAG RDGHCRLWTN CSQFGFLTMF PGNKTHNAVC IPEPLPTEQ
• Molecular Weight: Approximately 28-33 kDa due to the glycosylation
• References & Citations: [1]Tian J, et al. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682.|[2]Krausz LT, et al. GITR-GITRL system, a novel player in shock and inflammation. ScientificWorldJournal. 2007 May 1;7:533-66.|[3]Shin HH, et al. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage. FEBS Lett. 2002 Mar 13;514(2-3):275-80.|[4]Liu Y, et al. Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma. PLoS One. 2013 Jun 13;8(6):e66982.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years