GITR, Mouse (HEK293, Fc-His)

• UNSPSC Description:

  GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes[1]. GITR Protein, Mouse (HEK293, Fc-His) is a recombinant protein with a C-terminal Fc label and a C-terminal His label, It consists of 132 amino acids (S22-H153) and is produced in HEK293 cells.

• Type:

  Recombinant Proteins

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/gitr-protein-mouse-hek-293-fc-his.html

• Purity:

  98.0

• Smiles:

  SVVEEPGCGP GKVQNGSGNN TRCCSLYAPG KEDCPKERCI CVTPEYHCGD PQCKICKHYP CQPGQRVESQ GDIVFGFRCV ACAMGTFSAG RDGHCRLWTN CSQFGFLTMF PGNKTHNAVC IPEPLPTEQY GH

• Molecular Weight:

  Approximately 56 kDa

• References & Citations:

  [1]Tian J, et al. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682.|[2]Krausz LT, et al. GITR-GITRL system, a novel player in shock and inflammation. ScientificWorldJournal. 2007 May 1;7:533-66.|[3]Shin HH, et al. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage. FEBS Lett. 2002 Mar 13;514(2-3):275-80.|[4]Liu Y, et al. Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma. PLoS One. 2013 Jun 13;8(6):e66982.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Stored at -20°C for 2 years