Glucocorticoid Receptor alpha Rabbit Polyclonal Antibody

Glucocorticoid Receptor alpha Rabbit Polyclonal Antibody

• Description: Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state.
• Product Name Alternative: GCCR antibody GCR antibody Glucocorticoid receptor alpha isoform antibody Glucocorticoid receptor antibody GR antibody GRL antibody NR3C1 antibody Nuclear receptor subfamily 3 group C member 1 antibody
• Abbreviation: GR, NR3C1, GRL
• CAS Number: 9007-83-4
• Swiss Prot: P04150 Human, P06537 Mouse, P06536 Rat
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Glucocorticoid Receptor alpha aa 31-390.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: Hela, 293, A431.
• Concentration: 1 mg/mL
• Dilution: WB: 1:200-1:500;IF-Cell: 1:100-1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 86 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No