Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725]

Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725]

• Description: Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families. Most retinoid forms activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARα, RARβ and RARγ, have a high affinity for all transretinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. RAR isoforms are expressed in distinct patterns throughout development and in the mature organism. The human RARα gene maps to chromosome 17 and is implicated in the chromosomal translocation associated with acute promyelocytic leukemia (APL-M3). Specifically, the RARα gene is fused with the promyelocytic leukemia (PML) gene, which encodes the fusion protein PML/RARα. The PML/RARα fusion protein inhibits PML-dependent apoptotic pathways and halts myeloid differentiation at the promyelocytic stage.
• Product Name Alternative: NR1B1 antibody Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody Nuclear receptor subfamily 1 group B member 1 antibody Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody RAR alpha antibody RAR antibody RAR-alpha antibody rara antibody RARA_HUMAN antibody RARalpha antibody RARalpha1 antibody Retinoic acid nuclear receptor alpha variant 1 antibody Retinoic acid nuclear receptor alpha variant 2 antibody Retinoic acid receptor alpha antibody Retinoic acid receptor alpha polypeptide antibody
• Abbreviation: RAR-alpha, RARA, NR1B1
• CAS Number: 9000-83-3
• Swiss Prot: P10276 Human, P11416 Mouse,
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Retinoic Acid Receptor alpha aa 1-50 / 462.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, FC
• Positive Control: MCF7 cell lysate, SK-Br-3 cell lysate, HEK-293 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, MCF-7.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 51 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes