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PKM2 Rabbit Polyclonal Antibody

CAT: 0992-R1603-5Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1603-5Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival . Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).
CAS Number
9007-83-4
Product Name Alternative
CTHBP antibody Cytosolic thyroid hormone binding protein antibody Cytosolic thyroid hormone-binding protein antibody KPYM_HUMAN antibody MGC3932 antibody OIP 3 antibody OIP-3 antibody OIP3 antibody OPA interacting protein 3 antibody Opa-interacting protein 3 antibody p58 antibody PK muscle type antibody PK, muscle type antibody PK2 antibody PK3 antibody PKM antibody PKM2 antibody pykm antibody Pyruvate kinase 2/3 antibody Pyruvate kinase 3 antibody Pyruvate kinase isozymes M1/M2 antibody Pyruvate kinase muscle antibody Pyruvate kinase muscle isozyme antibody pyruvate kinase PKM antibody Pyruvate kinase, muscle 2 antibody TCB antibody THBP1 antibody Thyroid hormone binding protein 1 antibody Thyroid hormone binding protein cytosolic antibody Thyroid hormone-binding protein 1 antibody Tumor M2 PK antibody Tumor M2-PK antibody
Abbreviation
Pyruvate kinase PKM,Cytosolic thyroid hormone-binding protein CTHBP Opa-interacting protein 3 OIP-3 Pyruvate kinase 2/3 Pyruvate kinase muscle isozyme Thyroid hormone-binding protein 1 THBP1 Tumor M2-PK p58 PKM
Swiss Prot
P14618 Human, P52480 Mouse, P11980 Rat
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein corresponding to C terminal of Human PKM2 .
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
MDA-MB-231 cell lysate, SiHa cell lysate, NIH/3T3 cell lysate, Rat heart tissue lysate, Rat skeletal muscle tissue lysate, A549, NIH/3T3, PC-12, human lung cancer tissue, human testis tissue, mouse testis tissue, rat testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000 ;IF-Cell: 1:250 ;IHC-P: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 58 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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