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ACO1 Rabbit Polyclonal Antibody

CAT: 0992-R1512-16Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1512-16Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
CAS Number
9007-83-4
Product Name Alternative
ACO 1 antibody ACO1 antibody ACOC_HUMAN antibody Aconitase 1 soluble antibody Aconitase antibody Aconitase1 antibody Aconitate hydratase antibody ACONS antibody Citrate hydro lyase antibody Citrate hydro-lyase antibody Cytoplasmic aconitate hydratase antibody Ferritin repressor protein antibody IRE BP 1 antibody IRE-BP 1 antibody IREB 1 antibody IREB1 antibody IREBP antibody IREBP1 antibody Iron regulatory protein 1 antibody Iron responsive element binding protein 1 antibody Iron-responsive element-binding protein 1 antibody IRP 1 antibody IRP1 antibody OTTHUMP00000045233 antibody
Abbreviation
Aconitase, IRP1, IRE-BP 1, ACO1, IREB1
Swiss Prot
P21399 Human, P28271 Mouse, Q63270 Rat
Cellular Locus
Cytoplasm, cytosol.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human ACO1 aa 1-273 / 889.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Mouse liver tissue lysate, Hela, HepG2, human thyroid tissue, human kidney tissue, mouse thyroid tissue, mouse kidney tissue, mouse ovary tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 98 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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