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Bad Rabbit Polyclonal Antibody

CAT: 0992-R1511-32Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1511-32Size:100 µL
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Description
The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL:Bax complexes thereby causing restoration of Bax-mediated apoptosis.
CAS Number
9007-83-4
Product Name Alternative
AI325008 antibody BAD antibody BAD_HUMAN antibody BBC 2 antibody BBC2 antibody BBC6 antibody Bcl 2 Antagonist of Cell Death antibody Bcl 2 Binding Component 6 antibody BCL X / BCL 2 Binding Protein antibody BCL X Binding Protein antibody Bcl XL/Bcl 2 Associated Death Promoter antibody Bcl-2-binding component 6 antibody Bcl-2-like protein 8 antibody Bcl-XL/Bcl-2-associated death promoter antibody Bcl2 antagonist of cell death antibody BCL2 antagonist of cell death protein antibody BCL2 associated agonist of cell death antibody Bcl2 Associated Death Promoter antibody BCL2 binding component 6 antibody BCL2 binding protein antibody Bcl2 Like 8 Protein antibody Bcl2-L-8 antibody BCL2L8 antibody Proapoptotic BH3 Only Protein antibody
Abbreviation
BAD, Bcl2-L-8
Swiss Prot
Q92934 Human
Cellular Locus
Mitochondrion outer membrane, Cytoplasm
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Bad aa 1-50 / 168.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HepG2, SK-BR-3, SW480, human breast carcinoma tissue, MCF-7
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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