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Figla Rabbit Polyclonal Antibody

CAT: 0992-R1511-28Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1511-28Size:100 µL
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Description
Ovarian folliculogenesis is an intricate process involving interactions between germ and somatic cells in mammalians. FIGLA (folliculogenesis specific basic helix-loop-helix), also known as POF6, BHLHC8 or FIGALPHA, is a 219 amino acid nuclear protein expressed in fetal ovary and germ cells. FIGLA contains one basic helix-loop-helix (bHLH) domain and heterodimerizes with E12, a transcription factor that influences gene expression during B cell maturation. Acting as a germline specific transcription factor and a key player of ovarian folliculogenesis, FIGLA regulates the expression of multiple oocyte-specific genes that are required for fertilization and early embryonic survival. Mutations in the gene encoding FIGLA may be the cause of Premature Ovarian Failure (POF), a genetically heterogenous disorder that leads to hypergonadotropic ovarian failure and infertility. POF is characterized by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. FIGLA inhibits the expression of male germ cell specific genes during oogenesis.
CAS Number
9007-83-4
Product Name Alternative
bHLHc8 antibody Class C basic helix-loop-helix protein 8 antibody Factor in the germline alpha antibody FIGalpha antibody FIGLA antibody FIGLA_HUMAN antibody Folliculogenesis specific basic helix loop helix antibody Folliculogenesis-specific basic helix-loop-helix protein antibody POF6 antibody Transcription factor FIGa antibody
Abbreviation
FIGalpha
Swiss Prot
O55208 Mouse
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Mouse
Immunogen
Synthetic peptide within Human Figla aa 21-70 / 219.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell
Positive Control
Mouse three-cell embryos
Concentration
1 mg/mL
Dilution
IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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