PSD95 Rabbit Polyclonal Antibody

• Description:

  PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the?clustering of receptors, ion channels, and associated signaling proteins.PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density ofneurons,and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin,NMDA receptors,AMPA receptors, and potassium channels.It plays an important role in synaptic plasticity and the stabilization of synaptic changes during?long-term potentiation.

• Product Name Alternative:

  Discs large homolog 4 antibody Disks large homolog 4 antibody DLG 4 antibody Dlg4 antibody DLG4_HUMAN antibody FLJ97752 antibody FLJ98574 antibody Human post synaptic density protein 95 antibody Post synaptic density protein 95 antibody Postsynaptic density protein 95 antibody PSD 95 antibody PSD-95 antibody PSD95 antibody SAP 90 antibody SAP-90 antibody SAP90 antibody Synapse associated protein 90 antibody Synapse-associated protein 90 antibody Tax interaction protein 15 antibody

• Abbreviation:

  PSD-95,SAP-90,SAP90

• Swiss Prot:

  P78352 Human

• Cellular Locus:

  Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within N-terminal human PSD95.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P, FC

• Positive Control:

  A172 cell lysate, mouse brain tissue lysate, SHG-44 cell lysate, N2A cell lysate, rat brain tissue, mouse brain tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1000 ;IHC-P: 1:50 ;FC: 1:100

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 80 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4