AKR7A2 Rabbit Polyclonal Antibody

AKR7A2 Rabbit Polyclonal Antibody

• Description: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
• Product Name Alternative: AFAR antibody AFAR1 antibody AFB1 aldehyde reductase 1 antibody AFB1 AR1 antibody AFB1-AR 1 antibody AFB1AR1 antibody Aflatoxin aldehyde reductase antibody Aflatoxin B1 aldehyde reductase member 2 antibody Aflatoxin beta1 aldehyde reductase antibody Aiar antibody AKR7 antibody Akr7a2 antibody Aldo keto reductase family 7 antibody Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase antibody Aldo keto reductase family 7 member A2 antibody Aldo keto reductase family 7, member A2 (aflatoxin aldehyde reductase) antibody Aldoketoreductase 7 antibody ARK72_HUMAN antibody SSA reductase antibody Succinic semialdehyde reductase antibody
• Abbreviation: AFB1-AR 1,SSA reductase
• CAS Number: 9007-83-4
• Swiss Prot: O43488 Human, Q8CG76 Mouse, Q8CG45 Rat
• Cellular Locus: Mitochondrion, Golgi apparatus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide corresponding to Human AKR7A2 aa 101-150 / 359.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: 293T cell lysate, A431 cell lysate, Jurkat cell lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver tissue lysate, Hela.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 40 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No