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KLHL15 Rabbit Polyclonal Antibody

CAT: 0992-R1407-2Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1407-2Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization.
CAS Number
9007-83-4
Product Name Alternative
Kelch like 15 (Drosophila) antibody Kelch like 15 antibody Kelch-like protein 15 antibody KIAA1677 antibody KLH15_HUMAN antibody KLHL15 antibody MGC126148 antibody MGC126149 antibody OTTHUMP00000023075 antibody
Abbreviation
KLHL15
Swiss Prot
Q96M94 Human
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human KLHL15 aa 555-604 / 604.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell
Positive Control
HEK-293 cell lysate, HeLa cell lysate, Jurkat cell lysate, Hela, PANC-1.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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