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RIP3 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-12Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-12Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
CAS Number
9007-83-4
Product Name Alternative
Receptor interacting protein 3 antibody Receptor interacting serine threonine kinase 3 antibody Receptor interacting serine/threonine protein kinase 3 antibody Receptor-interacting protein 3 antibody Receptor-interacting serine/threonine-protein kinase 3 antibody RIP 3 antibody RIP like protein kinase 3 antibody RIP-3 antibody RIP-like protein kinase 3 antibody RIPK 3 antibody RIPK3 antibody RIPK3_HUMAN antibody
Abbreviation
Receptor-interacting serine/threonine-protein kinase 3 RIP-like protein kinase 3 Receptor-interacting protein 3 RIP-3 mRIP3 Ripk3 Rip3
Swiss Prot
Q9QZL0 Mouse, Q9Z2P5 Rat
Cellular Locus
Mitochondrion, Cytosol, Plasma membrane.
Host
Rabbit
Species Reactivity
Mouse, Rat
Immunogen
Synthetic peptide within Mouse RIP3 aa 440-486 / 486.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
MEF cell lysates.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 57 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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